Cannabinoids – The What and What For

 

What are Cannabinoids and What are the Top Cannabinoids in Cannabis?

Cannabinoids are chemical compounds that naturally occur in the cannabis plant (Cannabis sativa). The most notable of these are tetrahydrocannabinol (THC) and cannabidiol (CBD). These compounds can be used to treat many ailments and diseases, including cancer, diabetes, autoimmune disorders, chronic pain and inflammation, among others. Since the early 1900s, cannabinoids have been studied by researchers all around the world looking to determine their potential medical applications. Here’s what you should know about these amazing compounds.

Introduction to Cannabinoids

Cannabinoids are chemical compounds that act on receptors found in the human brain. In cannabis plants, they are primarily produced as a defense mechanism to protect against insects, bacteria, and fungi. They can also be used as a form of self-medication for people with neurological disorders like epilepsy. The two most common cannabinoids found in cannabis plants include THC (tetrahydrocannabinol) and CBD (cannabidiol). While THC is psychoactive, CBD is not. Recent studies have shown it’s possible to use CBD oil as an alternative treatment for some types of seizure disorders without experiencing any side effects. CBGVA has been shown to improve mood in patients who suffer from bipolar disorder. These four substances were just a few of many different cannabinoids we’ve observed in cannabis plants; more research will undoubtedly lead to new discoveries about their medical benefits.

There are three main categories of these chemicals, called cannabinoid receptors, which affect the human body. The first category, endocannabinoids, is produced within our bodies and interacts with cannabinoid receptors in our cells. The second category is phytocannabinoids (e.g., THC), which interact with cannabinoid receptors when we consume them from cannabis plants. The third category, synthetic cannabinoids, made in a forgein lab and interacts with cannabinoid receptors by mimicking natural cannabinoids or blocking natural ones

The Benefits of Cannabinoids

CBD is one of over 100 known cannabinoids. CBD and THC are the two most researched, but there are many other cannabinoids that have potential health benefits, including CBDV, CBN, CBG, CBC and THCA. Cannabinoids interact with receptors in our body called the endocannabinoid system. There are two main endocannabinoid receptors: CB1 and CB2. This system helps regulate many important functions in our body such as mood, appetite and pain sensation. The system includes two types of neurotransmitters: endogenous (made by your brain) and exogenous (made by plants).What are cannabinoids?: What are cannabinoids? Cannabinoids are compounds that can bind to cannabinoid receptors found in the body. They produce their effects primarily by binding themselves to these proteins and thereby influencing things like cellular communication, emotional state, sleep patterns and even memory formation. What does the endocannabinoid system do? The endocannabinoid system interacts with nerve cells in your brain (neurons), helping control how you perceive sensations like pain, heat or pleasure.

Cannabinoid Acids

Cannabinoid acids, more commonly referred to as just cannabinoids, are chemical compounds that act as natural mood stabilizers. The two most abundant cannabinoids found in cannabis are tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA). The process of conversion from THCA to THC is called decarboxylation; this process can be done through exposure to heat, light, or by leaving cannabis flowers out for a period of time. When heated, the THCA converts into its acidic form, CBGA. CBDVA (Cannabidivarinic acid) does not change when exposed to heat or light. CBGVA (Cannabigerovarinic acid), which is synthesized from THCVA (Tetrahydrocanabivarinic acid), converts into CBGVB if exposed to either heat or UV rays. CBCVA (Cannabichromevarinic acid) also does not change when heated.

CBDA (Cannabidiolic acid)

Cannabidiolic acid is an interesting cannabinoid because it’s a precursor to tetrahydrocannabinol (THC), one of the most well-known cannabinoids. When cannabidiolic acid is heated, it converts into THC. However, when consumed as an isolated compound, CBDA doesn’t create psychoactive effects like THC does. In fact, the reverse may be true; consuming high doses of CBDA has been shown to decrease anxiety by activating GABA receptors. it can help reduce pain or treat neurological disorders such as epilepsy.

Cannabidiol (CBD)

When talking about the different cannabinoids found in cannabis, one of the most discussed is cannabidiol, commonly referred to as CBD. What is CBD? It is a cannabinoid that has become increasingly popular in recent years due to its wide range of potential health benefits. Research has shown that it can help reduce inflammation, anxiety, depression, and even help fight cancer. It has also been linked to aiding in sleep, memory, and pain relief. CBD can be ingested in many different forms such as tinctures, edibles, topicals, and even vaping. However, the effects will vary depending on which form it was taken in. Tinctures are applied under the tongue or mixed with food and are absorbed more slowly than other methods but offer prolonged relief. Edibles take longer to absorb than tinctures but have strong effects when they do.Read more about CBD here.

Cannabidivarinic acid (CBDVA)

Cannabidivarin (CBDV)

CBDV has been found to possess anti-inflammatory, anticonvulsant, and anxiolytic properties, as well as being effective in treating certain neurological conditions. Studies have also demonstrated its ability to protect against oxidative stress and neurodegenerative diseases. As such, CBDV has become a popular option for those seeking relief from various physical and mental ailments.

In addition to its therapeutic benefits, CBDV has also been studied for its potential use in treating certain forms of epilepsy. A recent study showed that CBDV was effective in reducing seizures in mice, suggesting that it may be useful in treating certain types of epileptic disorders. While more research is needed in this area, these findings are promising.

CBDV can be found in many different forms, including tinctures, capsules, and edibles. It is important to note that CBDV can interact with other medications and supplements, so it’s important to consult with your healthcare provider before taking it. Additionally, it is important to purchase CBD products from reputable companies that test their products for quality and safety.

Cannabichromenenic acid (CBCA)

CBCA (Cannabichromenenic acid): Another important cannabinoid that makes cannabis more therapeutic than recreational is cannabichromene or CBCA for short. It’s not thought to be active at binding with either the CB1 or CB2 receptors like CBD, but instead activates another receptor called GPR18 which suppresses inflammation responses within the brain and body while triggering a sedative effect.

Cannabichromevarinic acid (CBCVA)

Cannabichromevarinic acid is one of at least 113 cannabinoids that has been isolated from cannabis plants. It is a minor constituent of hemp varieties grown primarily to produce fiber. This means it’s not as common as CBD, THC, or CBN. The most potent derivative of CBVA is CBCV (Cannabichromenic acid). So far, there haven’t been any studies done on its medical efficacy. But because it is an analogue of cannabichromene, it may have similar properties. In a study published by the International Journal of Legal Medicine researchers found that when rats were given doses equivalent to 1/10th and 1/5th human dosage, they did not exhibit typical side effects seen with other non-psychoactive cannabinoids like cannabidiol.

CBGA (Cannabigerolic acid)

CBGA is an acid that is found in the cannabis plant. It is the precursor to THC, CBN, and CBD. It can be used to decarboxylate other cannabinoids such as THCA into THC, or CBDA into CBD. The endocannabinoid system is responsible for regulating many physiological processes including appetite, immune response, moods/emotions, bone growth and repair as well as pain management. CBGA inhibits tumor cell proliferation and has been shown to inhibit a gene associated with aggressive breast cancer cells. The biosynthetic pathway of CBGA begins with geranyl pyrophosphate (GPP) which then produces cannabigerol (CBG). GPP is converted by cyclization to form either farnesyl pyrophosphate (FPP) or geranyl diphosphate (GDP). GDP then undergoes reduction reactions to form 2-trans-delta8-cis-tetrahydrocannabinol. FPP also undergoes reduction reactions to produce 2-cis-delta8-trans-tetrahydrocannabinol, but it does not give rise to tetrahydrocannabivarinic acid from the intermediate δ8 -THCV.

CBG (Cannabigerolic)

CBG is a non-psychoactive cannabinoid, meaning it doesn’t produce the same psychoactive effects as THC. CBG has been shown to have many therapeutic potentials and can be used in the treatment of inflammation, pain, and even cancer. In fact, CBG is thought to work synergistically with other cannabinoids such as CBD and THC. Some research suggests that CBG may also be able to block some of the negative side effects caused by THC such as anxiety or paranoia.CBG has yet to be extensively researched for its medicinal properties but there are promising signs that this cannabinoid could hold a wealth of information about how cannabis can help our bodies heal.Learn more about CBG here! What are cannabinoids? Cannabinoids (CBD, THC, etc) are chemical compounds that come from the cannabis plant. Different cannabinoids interact with receptors in your brain and body differently to produce different effects on your health – this is what’s referred to as their mechanism of action.

Cannabigerovarinic acid (CBGVA)

Cannabigerovarinic acid, or CBGVA, is one of many cannabinoids found in cannabis. CBGVA is a product of cannabigerolic acid (CBGA) and can be converted to tetrahydrocannabinol (THC) via decarboxylation. CBGVA has been shown to have anti-inflammatory properties with moderate efficacy as an antibiotic against certain species of bacteria. It also possesses antiviral activity and is used in vitro for treating fungal infections. CBGVAs potential to inhibit cancer cell growth has been investigated but was not conclusive.

Cannabicyclol (CBL)

Two other lesser-known cannabinoids present in CBD oil are cannabicyclol (CBL) and cannabicyclolic acid (CBLA). These two compounds work together to produce unique effects in the body. CBL has been shown to exhibit anti-inflammatory, anti-cancer, antioxidant, and neuroprotective properties. CBLA can act as an agonist at CB1 receptors, which can be beneficial for mood disorders. Together, CBL and CBLA are a powerful combination for those seeking relief from inflammation and pain.

Cannabicyclolic acid (CBLA)

CBD oil has become a popular health supplement due to its potential therapeutic benefits. It is a natural extract derived from the Cannabis plant, and it contains cannabidiol (CBD) as one of its main components. Alongside CBD, there are several other cannabinoids found in CBD oil, such as cannabicyclolic acid (CBLA).

CBLA is thought to work synergistically with other compounds found in CBD oil, such as CBD and CBDA, to create an even more powerful therapeutic effect. For this reason, many people use CBD oil for their health concerns in order to take advantage of the combined benefits of all of these compounds.

If you’re looking to reap the therapeutic benefits of CBD oil, make sure to check if it contains CBLA. It could be the key to unlocking even more of CBD oil’s potential benefits!

Cannabicyclovarin (CBLV)

CBD oil has become increasingly popular in recent years due to its many potential health benefits. One of the compounds found in CBD oil is cannabicyclovarin (CBLV). CBLV is an analog of the cannabinoid THC, and has been studied for its potential anti-inflammatory, anti-anxiety, and anti-nausea properties.

CBLV interacts with the body’s endocannabinoid system by binding to the CB1 receptor in the brain. This interaction can help reduce inflammation, anxiety, and nausea. In addition, CBLV may also be helpful for treating seizures, as studies have shown it to be effective in reducing the severity and duration of seizures in mice.

Overall, CBLV is an important compound to be aware of when considering CBD oil as a natural treatment for various health issues. While more research is needed to fully understand its effects and benefits, current research suggests that CBLV could be an effective option for those looking for natural remedies to treat various health conditions.

Cannabidivarinic acid (CBDVA)

CBDVA is a non-psychoactive cannabinoid found naturally in cannabis. Unlike THC, CBDVA does not produce any kind of psychoactive effects, but it can still be used to create them by mixing it with other cannabinoids like THC.There is not much research on CBDVA specifically, but some studies have been done on rats. These studies found that CBDVA helped to reduce nausea and vomiting without any unwanted side effects. It may also help reduce anxiety and depression, as well as inflammation. The amount needed for these effects is not known at this time, so more research needs to be done before we know if this is true. However, one study suggested that CBDVA might be an effective treatment for certain symptoms of fibromyalgia and multiple sclerosis. Studies have also shown it to act as an antioxidant which can protect against cellular damage from free radicals.

 Δ9-tetrahydrocannabinolic acid (THCA)

Unlike most cannabinoids, THCA is not psychoactive. This cannabinoid is also known as a precursor because it can be converted to THC. Other cannabinoids that can be converted to other cannabinoids include CBGA (Cannabigerolic acid) to CBGVA (Cannabigerovarinic acid), CBDA (Cannabidiolic acid) to CBDVA (Cannabidivarinic acid), CBCA (Cannabichromenenic acid) to CBCVA (Cannabichromevarinic acid).There are more than 100 different types of cannabinoids found in cannabis, but only some of them provide a wide range of health benefits. For example, cannabidiol is widely used for its ability to counteract seizure disorders and for its anxiolytic effects. In contrast, tetrahydrocannabinol or THC is highly psychoactive due to its ability to bind with cannabinoid receptors in your brain allowing you to feel high . The other four best-known cannabinoids are cannabigerol or CBG , cannabichromene or CBC , cannabigerovarinic acid or CBGV and cannabinolic acid or CBNA . All these compounds have medicinal properties.

Delta-9-tetrahydrocannabinol (THC)

What is Delta-9-tetrahydrocannabinol (THC)? THC is the main psychoactive component of cannabis and is responsible for its characteristic high. It works by binding to cannabinoid receptors in the brain and produces a range of effects, such as changes in mood, appetite, and perception. THC can also cause increased heart rate, red eyes, dry mouth, and other physical side effects. Research has shown that THC may have medicinal benefits as well, such as reducing pain and inflammation.

Delta-9-tetrahydrocannabivarin (THCV)

Have you ever wondered what is Delta-9-tetrahydrocannabivarin (THCV)? THCV is a phytocannabinoid found in some strains of cannabis, including the famous sativa strain Durban Poison. It is similar in structure to tetrahydrocannabinol (THC), but has slightly different effects. THCV is known to have appetite suppressing properties, and can provide an energizing and clear-headed high. It has also been shown to reduce anxiety and stress, and may help improve physical performance. Research is still being conducted on the benefits of THCV, so be sure to keep an eye out for new developments in this area.

Tetrahydrocanabivarinic acid (THCVA)

THCVA is a non-psychoactive cannabinoid that is an analogue of THC. It was first isolated by Shimon Ben-Shabat, Yechiel Gaoni, and Raphael Mechoulam in 1998. It has a melting point at 186 degrees Celsius, which is lower than THC’s melting point of 188 degrees Celsius. This may make it more difficult to extract from cannabis. Its boiling point is 220 degrees Celsius, which makes it volatile when heated to high temperatures like THC. When heated up with cannabigerolic acid (CBGA), you can get tetrahydrocannabivarin carboxylic acid (THCVC) instead of THCVA.

The difference between THC and CBD

A cannabinoid is a compound found in cannabis plants. To date, over 100 different cannabinoids have been identified, but THC and CBD are the two that capture most of the attention. Tetrahydrocannabinol (THC) is one of the best-known compounds, and it’s responsible for causing marijuana’s psychoactive effects. Cannabidiol (CBD) is another common component of cannabis; this non-psychoactive compound has been shown to reduce some types of pain, inflammation, swelling and more. Another major difference between these two compounds is their chemical structure. THC contains three rings with an amine group attached to them at positions 2, 6 and 11 on the pentyl chain. CBD also includes three rings, but they have a propyl chain instead of pentyl chain with no amine group on position 3. These differences mean that they interact with each other differently when ingested or smoked – meaning you can still get high even if you consume CBD.Also noteworthy is that while research suggests there are many potential benefits of CBD use (like managing nausea), THC has only been proven beneficial when used in conjunction with chemotherapy treatment because its toxic properties can be used against cancer cells while sparing healthy cells around them from damage.

The difference between CBC and CBGV

CBC is a cannabinoid that has been found to have anti-inflammatory properties, while CBGV is a cannabinoid that has been shown in preliminary research to offer neuroprotection. The two compounds also differ slightly in their molecular composition. Despite the differences, both CBC and CBGV are not as prevalent in cannabis plants as THC and CBD. However, CBC can be found in some European hemp varieties and CBGV can be found in some strains of cannabis from South Africa.

What’s the difference between CBG and THCA?

Cannabis contains many forms of the molecule known as tetrahydrocannabinolic acid (THCA). When this molecule is heated or cured it becomes decarboxylated and converts into another molecule called Δ9-tetrahydrocannabinol (Δ9-THC), which then binds to CB1 receptors in the central nervous system. Thus, what we know as raw marijuana often doesn’t contain any detectable amounts of psychoactive chemicals like Δ9-THC. Instead, it’s converted into what we call activated marijuana when it’s smoked or vaporized for medicinal purposes

 The difference between CBDV and CBGV

CBCV is the chemical name for cannabichromevarin, which was reclassified as CBDV in 2010. One of the primary differences between these two compounds is that CBCV has a higher boiling point (around 212°F or 100°C) than CBDV (around 185°F or 85°C). Cannabichromevarin also seems to be more potent than cannabidivarin, with an estimated potency of 1.5%.

 What are synthetic cannabinoids?

The dangers of synthetic cannabinoids are real, as evidenced by a growing number of reports of deaths and negative research findings. Synthetic cannabinoids are man-made chemicals that are sprayed onto plant material or smoked to create a similar feeling to smoking marijuana. While the effects may be similar, the ingredients in synthetic cannabinoids are much more potent and have been linked to an increase in emergency room visits, serious health issues, and even death. See more about synthetic cannabinoids here. 

Conclusion

Cannabinoids are a class of chemical compounds that interact with receptors located throughout the body to produce pharmacological effects. Tetrahydrocannabinol is one of many cannabinoids found in cannabis. THCV has been shown to suppress appetite and may be useful for people trying to lose weight. CBD has been shown to reduce or eliminate seizures due to epilepsy, as well as provide relief for those suffering from chronic pain. CBDA may have anti-inflammatory properties; however, it needs more research before any claims can be made about its medicinal benefits.

CBN is non-psychoactive and is mainly used for its ability to help treat insomnia. Another cannabinoid, CBGA (Cannabigerolic acid) is also non-psychoactive but instead helps regulate physiological functions including sleep cycles. Another important cannabinoid is CBCA (Cannabichromenenic acid) which has strong anti-inflammatory properties and may even have some antibiotic qualities. It’s worth noting that these findings are still preliminary and require further research.

It is important that if you are going to try a Full Spectrum hemp CBD Oil that contains a rich robust blend of cannabinoids. The Genesis Blend Hemp Extract CBD Oil has more cannabinoids and terpenoids than any other brand on the market.